ABSTRACT
Background: Bisphenol A [BPA] is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. Exposure of rats to low doses of BPA results in histopathological effects in their retina
Objectives: We used histological and immunohistogical techniques for determining retina pathological changes in response to low doses of BPa and the modulating effect of both vitamin A and stem enhancer
Methods: Twenty female albino rats orally administered with 20mg BPA/kgb.wt/day for 45 days and then divided to groups and treated with vitamin A and stem enhancer. Both eyes were examined histological and immunohistochemicaly to determine the histologically changes in retinal layers
Results: Aremarkable degenerative histopathological changes in the ganglion cell layer and inner nuclear layer appeared with bis phenol treated rats and a clear improvement was seen after the treatment with both vitamin A and stem cell enhancer
Conclusion: Both of vitamin A and stem enhancer have amelorative effect on the degenerative changes in the retinal layers and damaged estrogen receptors by the action of bisphenol A